Medical Laboratory Scientist (MLS) ASCP Practice Exam

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What does the classification M0 indicate in myeloid leukemia?

Myeloblast with minimal maturation

Myeloblast without differentiation

In the classification of myeloid leukemia, the designation of M0 specifically refers to myeloblasts that do not show any differentiation. This means that the cells are predominantly undifferentiated myeloblasts, which are immature cells that have not begun to mature into more specialized forms of myeloid cells such as neutrophils, eosinophils, or basophils.

This classification is important because it helps define the aggressiveness and nature of the leukemia, as more advanced stages (represented by higher classifications such as M1 to M5) involve varying degrees of maturation, indicating that these cells are beginning to develop into more differentiated types, which could impact treatment decisions and the overall prognosis for the patient. Therefore, the M0 classification indicates a more primitive and aggressive type of myeloid leukemia.

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Myeloblast with moderate maturation

Myeloblast with full differentiation

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